New paper published: Computing Arithmetic Functions Using Immobilised Reaction Networks

Nikita, Mathieu, Lía and Wilhelm together with Max Derks from Laboratory of Spectroscopy and Catalysis and Labmate published a new paper on enzyme-based computation! They used proteolytic enzymatic networks immobilised in hydrogel beads and compartmentalised in a CSTR as a novel platform for molecular information processing. They demonstrated robustness of the platform in performing the fundamental arithmetic operations of addition, subtraction and multiplication. This analogue logic approach goes beyond the Boolean gates and has potential applications in future bioelectronic devices. The concept of analogue logic helps to generalize our understanding of computation in catalytic networks.Congratulations!!

You can find the paper here.

Kinga’s goodbye party

Last Friday our postdoc Kinga Matuła said goodbye to the group as she is now fully focused on her new start-up called QurieGen! We want to thank Kinga for all those great years in the Huck group and wish you all the best in the future! We will miss you!

Secret Sock Santa

Right before Christmas holiday our POC department celebrated Secret Sock Santa!🧦🎅 This is our annual tradition in which we gift special socks and also write a personal poem! This brought a lot of joy and laugh to all of us!

 

Dr. Maas

Last Tuesday (13 December, 2022) Roel Maas successfully defended his PhD thesis entitled “A microfluidic approach for forward design of modular cell-free genetic networks”. Roel became #22 Dr. in the Huck group!

Congratulations Dr. Roel!

Photo credit: Wim Steenbakkers

CLASSY meeting in Nijmegen

On the 15th-16th November 2022 Huck group was hosting the 8th General Assembly meeting of CLASSY consortium. During the 2-day hybrid meeting partners from Universidad Autónoma de Madrid (UAM), Ben-Gurion University of the Negev (BGU), ETH Zürich (ETH), Universität Graz (UG) and Micronit B.V. (MICRONIT) presented latest research updates and challenges. Miglė Jakštaitė, Tao Zhou and Wilhelm Huck were representing our group. Current and future collaborations were also discussed to reach our challenging milestones. accelopment Schweiz AG (accelCH) gave an overview of our project status and was moderating the brainstorm sessions. It was great to host such incredible teams and share our ideas!

Click here to read more about our recent meeting.

Anual sIMMposium

During this year’s annual sIMMposium organised by Institute of Molecules and Materials (IMM) at Radboud University Dr. Will Robinson presented his recent study on a prebiotic reaction network and origins of life.

If you still haven’t read the paper, you can find it here.

New paper on photobiocatalysis in flow conditions

New article on photobiocatalysis in flow was published in ACS Biocatalysis in a collaboration with the group of Wolfgang Kroutil from Graz University!

In this paper immobilised photodecarboxylase from C. variabilis (CvFAP) is taken as an example to demonstrate the methodology development of photobiocatalysis in flow conditions. Various enzyme immobilisation techniques were used to determine the best carrier and conversion.

Congratulations to Stefan, Christoph and Wolfgang from Graz University as well as Miglė and Wilhelm!

You can read the paper here.

National Growth Fund application has been awarded 96.9 M Euros

Fantastic news! The National Growth Fund application for ‘RobotLab’ has now been awarded 96.9 million Euros unconditionally! Chemistry an AI will be combined together to build a fully robotic lab.

Big congratulations to Wilhelm and collaborators!

Learn more about this (in Dutch) here.

Emma Keizer – new postdoc

Emma is a computational systems biologist who enjoys working in multi-disciplinary research teams. During her Ph.D. research, she studied noisy gene expression networks to investigate the implications of cell-to-cell variability on cellular fitness through a combination of experimental (single-cell) analysis and mathematical modelling. Her work in the Huck group is focused on designing mathematical models to investigate how signalling networks respond to external stimuli, and the analysis of multi-omics single-cell data. Outside of work, Emma is a keen cyclist and loves to learn new skills.

Welcome Emma to the group!

CHAINS 2022

The Huck group was well represented this year at CHAINS – the main chemistry conference for chemists in the Netherlands. One of our postdocs, Oliver Maguire, presented his recent work on a prebiotic phosphorylation system for creating phosphorylated molecules critical to the Origins of Life. Many members of the group also presented their work in the poster sessions.

 

More details on Oliver’s work on prebiotic phosphorylations can be found in a recent paper here: https://doi.org/10.1038/s41467-021-25555-x